Crixmor LLC 
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Significant and Growing Market- Key Factors Driving Demand

  • Aging population

    • According to the US census bureau in 2008 there were 39 million people over 65 , this is expected to  grow to 71.5 million by 2030

  • Obesity

    • According to the CDC 34% of Americans age 20 and older were obese in 2007-08

    • When people who are overweight are added over 2/3rds of adults are obese

  • Diabetes

    • American Diabetic Association estimates  23.6 million Americans over 20 have diabetes,

    • 1.6 million new cases diagnosed each year

    • Over 1.8 million with chronic wounds

  • 71,000 non traumatic lower limb amputation annually in the US, 60% are diabetic

    • Causes: diabetes, obesity, peripheral vascular disease  

  • Osteoarthritis
    • Affects more than 70% of adults between 55 and 78 years of age
    • 107,000 patients hospitalized annually for prescription non-steroidal anti-inflammatory drug (NSAID) related gastrointestinal (GI) complications in osteoarthritis patients

 


  • The "Graying" of America- The "baby boomer" generation, those born between 1946 and 1964, are aging. By 2025, 1 in every 5 Americans will be over 65. Many Baby Boomers made exercise a routine in their life schedules and as they age, they have become Senior Athletes.  Since the majority of exercises rely heavily on our feet and knees increasing age is associated a need for greater care of the lower extremities. Advancing age is also associated with chronic vascular problems such as peripheral arterial disease (PAD) a chronic arterial, occlusive disease of the lower extremities caused by atherosclerosis and linked to diabetes.

  • Obesity is a known risk factor for many diseases.  Osteoarthritis of the knee and lower extremity venous insufficiency leading to chronic wounds are directly linked to obesity. Morbidly obese patients have a 20% incidence of type 2 diabetes which, in addition to the difficulty of maintaining adequate hygiene, increases the likelihood of bacterial and fungal infection.

  • The epidemic of Diabetes has increased the demand for products to treat infection and wounds. The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), estimates over 20 million Americans have diabetes.  There are 1.8 million diabetics with chronic wounds. Diabetes is a known risk factor for PAD.  Over 15% of diabetics will develop some form of foot ulcers, an important cause of morbidity and mortality.  Up to 83% of the estimated 125,000 lower-extremity amputations performed annually can be directly attributed to diabetes.  With a higher mortality than many cancers, after an amputation, 70% of patients die within five years, according to the National Institutes of Health.  Drugs to reduce the risk of amputation or treat diabetic foot ulcers can readily demonstrate cost-effectiveness.  Crixmor has products that will address this need.

  • Osteoarthritis (OA), the most common form of arthritis in the United States is a disease affecting all joint structures, not just hyaline articular cartilage. OA develops as a consequence of injurious activities acting on a vulnerable joint. Risk factors include age, obesity, and joint injury. The incidence of OA is increasing as the population ages and is likely to rise further with the obesity epidemic. Significant disability and loss of function are associated with this disease, and its management is an enormous cost to the health care system. Osteoarthritis affects more than 70% of adults between 55 and 78 years of age.